Endocrine Abstracts

Inflammation and dysfunction of the hypothalamus is a common feature of experimental diet-induced obesity. As in any inflammatory process, both pro- and anti-inflammatory activity is expected to take place in the hypothalamus of obese animals. Here, we test the hypothesis that consumption of a saturated fatty acid-rich diet can modulate the activity of the important immunomodulatory system of the resolvins in the hypothalamus. Swiss mice were fed for 8 or 16 weeks (w) either o...